Lionheart Health, Inc. has announced the start of enrollment for its Lionheart Klotho-Up™ Study, a longitudinal program designed to assess whether a structured wellness and bioelectric intervention program may support key markers of healthy aging. The study focuses on the Klotho protein, widely recognized as an important longevity-associated protein linked to multiple aspects of healthy aging, including muscle function, brain health, vascular and metabolic health, inflammation balance, and overall healthy aging biology.
The study is built around two core required elements: daily Klotho-favoring meals, supplements, and beverages, and BodStim™ Klotho-enhancing exercise performed two or three times per week for one hour per session. Participants may also choose from optional supportive therapies, such as hyperbaric oxygen therapy, red light therapy, cold therapy, pulsed electromagnetic field (PEMF) therapy, and organ-targeted bioelectric stimulation, depending on availability and site offerings.
Howard Leonhardt, Executive Chairman and co-CEO of Lionheart Health, stated the company's goal is to make a Klotho-supportive lifestyle and bioelectric wellness program more structured, measurable, and accessible. He emphasized that many individuals seek guided programs with objective testing to track improvements in muscle, cognitive, and immune health over time, rather than vague longevity advice.
All participants must complete a formal informed patient consent process and agree to required baseline and one-year follow-up assessments. Core assessments include muscle health evaluations (grip strength, gait speed, 6-minute walk test, muscle mass assessment), brain health testing (standardized cognitive testing, memory testing, mood assessment), and immune health analysis (gut intelligence testing and various biomarkers). Additionally, all participants must complete a 461 blood biomarker panel at baseline and one year, with optional testing at 3 and 6 months. An AI-enhanced MRI through CoreViva is available optionally for deeper body composition insights.
Enrollment is opening on a limited basis for qualified participants at licensed clinic locations. This is a subsidized paid registry study where patients pay $12.99 per day for Klotho-favoring meals delivered to their home or can follow provided recipes to reduce costs to approximately $5 to $7 per meal. The BodStim™ EMS suit can be leased for one year with an $890 down payment and monthly payments of $188. The 461 biomarker test costs $800 each for non-members and $463 for members. Lionheart Health will cover all muscle, brain, and immunity health test assessments at baseline and one year, while optional AI-enhanced MRI scans and additional biomarker tests are covered by patients.
The study also supports Lionheart Health's participation in XPRIZE Healthspan, where the company was named a Top 40 Milestone 1 awardee semi-finalist from more than 600 registered teams worldwide. This reflects the strength of its proposed therapeutic approach, preliminary data, and clinical testing strategy. For more information, visit Lionheart Longevity.
The Lionheart Klotho-Up™ Study is intended for research, wellness, and health optimization purposes, requiring informed consent. Individual results may vary, and optional therapies are subject to eligibility criteria and regulatory limitations. This announcement is not intended as medical advice or a claim of diagnosis, treatment, cure, or prevention of disease.
