MyBioSource has expanded its catalog of life science reagents with the addition of a validated sheep anti-rat calretinin (CALB2) polyclonal antibody, designated MBS502148. This antibody targets calretinin, a 29 kDa calcium-binding protein predominantly expressed in neurons throughout the central nervous system, retina, and other tissues, playing critical roles in intracellular calcium buffering, cellular homeostasis, and neuroprotection.
The antibody recognizes rat calretinin protein and, due to 100% sequence homology, offers potential cross-reactivity with mouse, human, and non-human primate calretinin. It is purified using Protein A to ensure high specificity and low background noise, and is stable at -20°C, though researchers are advised to avoid repeated freeze-thaw cycles. Key validated applications include Western blot (WB), immunohistochemistry (IHC) on formalin or paraformaldehyde-perfused rat brain tissues, and immunofluorescence (IF).
This development is significant for neuroscience research, particularly in studies of neurodegeneration, calcium signaling mechanisms, auditory neurons, and neuronal resistance to excitotoxicity. Calretinin serves as an important marker in neurological studies, aiding in the analysis of calcium dynamics and contributing to the understanding of neuroprotective pathways. The antibody supports academic and research efforts aimed at elucidating calcium regulation, neuronal function, and related biological processes, with relevance to developmental biology and auditory neuroscience.
The anti-CALB2 antibody is intended for research use only and is not suitable for diagnostic, therapeutic, or clinical applications. Researchers must follow appropriate laboratory safety guidelines and validate antibody performance under their specific experimental conditions. For further details, visit www.mybiosource.com.
