Springs Rejuvenation, a physician-led regenerative medicine practice, has expanded its proprietary Stem 3 Protocol to all five of its United States locations, making exosome-based hair restoration available to patients in New York City, Los Angeles, Austin, Miami, and Atlanta without the need to travel abroad. The expansion marks a significant step in bringing advanced non-surgical hair restoration to a broader domestic audience.
The Stem 3 Protocol combines three components delivered in sequence: peptide therapy, exosome hair treatment, and micro follicular unit extraction (micro FUE) performed with 0.9mm instrumentation. This smaller incision diameter, compared to conventional FUE punches of 1.0mm to 1.5mm, is designed to minimize scalp trauma and support faster tissue recovery. Exosomes, extracellular vesicles derived from stem cells, carry signaling proteins and growth factors that communicate with hair follicle cells. In the protocol, they are applied to prime the scalp environment before and after the micro FUE procedure, aiming to extend the active growth phase of the hair cycle and reinforce follicle density over time. The peptide therapy component is administered as a preparatory measure to optimize cellular conditions in the scalp.
Until recently, patients seeking non-surgical hair restoration using exosome-based protocols typically pursued treatment at clinics in Europe, Mexico, or Southeast Asia, where regulatory frameworks for regenerative therapies have historically been more permissive. Springs Rejuvenation's multi-city expansion positions the practice as one of the few domestic providers delivering this combination protocol at scale across multiple US states. "With five active clinic locations, we have now treated patients in every major US time zone under the Stem 3 Protocol," said Dr. Charles Pereyra, MD, Medical Director of Springs Rejuvenation. "Our 0.9mm micro FUE instrumentation paired with exosome hair treatment means patients are no longer choosing between quality and convenience - they can access this level of care in their home city."
Each of the five clinics operates under direct physician supervision. The practice also offers stem cell exosome therapy for joint conditions alongside its hair restoration programs, positioning the clinics as integrated regenerative medicine centers. Hair restoration without surgery has become an increasingly documented area within regenerative medicine, with published research examining exosome signaling in dermal papilla cells, the specialized cells responsible for initiating and sustaining hair follicle activity. Springs Rejuvenation applies this science within a structured clinical framework, with each patient undergoing an intake assessment before the Stem 3 Protocol is initiated.
The expansion of the Stem 3 Protocol to five US cities provides patients with a domestic option for advanced exosome-based hair restoration, potentially reducing the need for medical travel and expanding access to cutting-edge regenerative treatments. For more information, visit Springs Rejuvenation.
