Tonix Pharmaceuticals Develops Promising Single-Dose Mpox Vaccine with Broad Protection

Pharmaceutical company Tonix Pharmaceuticals has revealed promising preclinical data for its single-dose mpox vaccine candidate, TNX-801, presenting significant potential for addressing global public health challenges related to mpox outbreaks.

The research, presented at the World Vaccine Congress Washington 2025, highlighted the vaccine's robust efficacy in protecting animal subjects against mpox and rabbitpox. Notably, the vaccine demonstrated sustained immune protection lasting six months and showed effectiveness across various subject types, including immunocompromised populations.

TNX-801 represents a minimally replicative live-virus vaccine that aligns with the World Health Organization's preferred vaccine profile. This characteristic positions the vaccine as a potentially critical tool in managing current and future mpox global health emergencies.

The vaccine's development is particularly significant given the recent mpox outbreaks that have challenged public health systems worldwide. By offering a single-dose solution with extended protection, TNX-801 could represent a breakthrough in vaccination strategies against this infectious disease.

The preclinical study results suggest TNX-801 could provide a versatile and comprehensive approach to mpox prevention. Its ability to generate durable immune responses across different subject groups indicates potential for broad applicability in diverse populations and geographic regions.

Tonix Pharmaceuticals' research underscores the ongoing importance of innovative vaccine development in addressing emerging infectious diseases. The company's work demonstrates a proactive approach to public health preparedness, focusing on creating adaptable medical solutions for complex health challenges.

As global health landscapes continue to evolve, vaccines like TNX-801 represent critical advancements in our collective ability to respond rapidly and effectively to potential viral threats. The research offers hope for more efficient and comprehensive disease prevention strategies in the future.