The strategic partnership between Lionheart Health and Rejuvant represents a significant development in the field of longevity science, as the companies combine validated nutritional interventions with advanced technologies in their bid to advance in the XPRIZE Healthspan competition. This collaboration brings together peer-reviewed research on biological aging with comprehensive health monitoring systems, potentially establishing new standards for how healthspan extension is measured and achieved.
Under the partnership, Rejuvant's patented Calcium alpha-ketoglutarate (CaAKG) supplement becomes a mandatory core component of Lionheart Health's KLOTHO-UP™ Study and broader Klotho Wellness Program. This integration is particularly significant because CaAKG has demonstrated improvements in biological age markers through peer-reviewed research, providing a scientifically validated foundation for the broader intervention program. The collaboration positions Lionheart Health's approach as one that combines established metabolic biology with emerging technologies.
The Lionheart KLOTHO-UP™ Study represents a comprehensive, technology-driven healthspan platform that extends beyond simple supplementation. In addition to Rejuvant CaAKG, participants receive SNiP Nutrition™ personalized supplements customized based on genetic and biomarker profiles, targeted Klotho-focused supplementation, and access to Lionheart Health's BodStim™ bioelectric exercise platform. This platform delivers Klotho- and follistatin-elevating electrical muscle stimulation-enhanced exercise sessions, typically one hour, two to three times per week. This integrated approach reflects the growing understanding that meaningful healthspan extension requires coordinated interventions across multiple biological systems.
What makes this initiative particularly noteworthy is its extensive measurement protocol, which enables deep, longitudinal tracking of healthspan outcomes. Participants undergo comprehensive testing at baseline, three months, six months, and twelve months, including a 461-biomarker blood panel with klotho levels, AI-enhanced full-body MRI with targeted organ and tissue analysis, muscle health assessments, gut health and microbiome evaluation, and brain health testing covering cognition, memory, and mood metrics. This rigorous approach moves beyond single-endpoint measurements to provide a holistic view of functional healthspan changes over time.
The partnership's significance extends beyond the individual companies to the broader field of longevity science. By combining Rejuvant's rigorously studied nutritional intervention with Lionheart Health's multi-modal platform, the collaboration demonstrates how different approaches to healthspan extension can be integrated for potentially greater effect. The program's inclusion in the XPRIZE Healthspan Semi-Finals, where Lionheart Health was selected as a top 40 semi-finalist out of more than 600 entries, further validates the scientific merit of this approach.
For individuals interested in the Klotho Wellness Program, more information is available at https://lionheartlongevity.com/treatment/klotho-wellness-program/. The program's comprehensive nature, combining supplementation, personalized nutrition, bioelectric exercise, and extensive biomarker tracking, represents a new model for healthspan optimization that could influence how aging interventions are developed and evaluated across the longevity industry.
